125. Why We Age and the Science of Longevity with David Sinclair

What if you could slow down the clock on your aging? According to aging expert and Harvard geneticist, Dr. David Sinclair, we now have the knowledge and technology to live longer lives, healthier. In his revolutionary research, Dr. Sinclair has identified mechanisms behind aging giving us clues into the behaviors and molecules that can potentially extend life. 

Listen and Learn:

  • Why is aging a disease and how can it be slowed
  • What are longevity genes and what role do they play in health
  • What is epigenetics and how does it relate to aging and health
  • What is hormesis and why is being too comfortable bad for our longevity
  • What behavioral strategies can you start today that will lead to a longer life
  • What molecules Dr. Sinclair’s lab is researching that could be our future fountain of youth
  • What are the social and individual impacts of living longer with more health
  • What does Dr. David Sinclair do each day to activate his longevity genes


About David Sinclair

David A Sinclair

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freeman’s “Through the Wormhole” and other media. He is an inventor on 35 patents and has received more than 25 awards and honors including the TIME magazine’s list of the “100 most influential people in the world”.

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Episode 125